Reference management software: EndNote

1. Open EndNote
2. Go to File and choose New
3. Save your EndNote library on your computer (never on a network area or a cloud storage)

When you create an EndNote library, a folder with the suffix .Data is also created. This folder and your EndNote library must always be saved at the same location on your computer.

There is also the option to merge the two files into one package. By choosing this option you don't need to remember to move the two files each time you need to move your library or make a back up. Check the box Save as Package

You can have one or several EndNote libraries but it is recommended that you keep only one library.

iCloud

Never store your EndNote library in a network or cloud storage such as Dropbox or iCloud. If your Mac has been set to sync your Desktop and Documents with iCloud, you must not save your EndNote library on the Desktop or in the Documents folder. Instead, you can create a folder within the Applications folder for storing your EndNote library. Read more about EndNote and iCloud.